Nana Amo, 8 and Nana Boadi, 5, met their untimely death when their room got gutted by fire, burning them to death.
Nana K, uncle of the deceased told the media that, his brother called him around 2 am that there is a fire outbreak in the house and his two children have been trapped in the fire.
They managed to quench the fire with the help of the Fire Service but the children were burnt beyond recognition.
The cause is, however, not immediately known.
The bodies have been deposited at the Police Hospital morgue and investigations are ongoing.